[Use of tenofovir monotherapy in a cohort of prisoners confined in the prisons of the Molise region and affected by mild HBV-related chronic hepatitis]

Roberto Patriarchi, Antonio Di Nicola, Orazio Grassi, Giuseppe De Bartolomeo

DOI: https://doi.org/10.7175/cmi.v9i4.1218

Abstract

Inmates are a population at risk for hepatitis B virus infection. It affects about 2% of Italian prisoners, while the prevalence in the Molise region seems to be higher, accounting for around 4% of the inmates.

The Authors report their experience in a penitentiary in the management of chronic hepatitis B with tenofovir. In particular, 10 male patients affected by HBV-related chronic hepatitis naïves to treatment confined in the prisons of the Molise region were treated with tenofovir 245 mg/die. The results show a satisfactory response, excellent tolerance, and no interruptions.

[Article in Italian]

 

Keywords

Tenofovir; HBV; Hepatitis B; HBV-DNA; HBsAg

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References

  • Di Fiandra T, Voller F, Bazzerla G, et al. La salute dei detenuti in Italia: i risultati di uno studio multicentrico. Collana Documenti dell’Agenzia Regionale di Sanità della Toscana 2015; 83: 1-454. Disponibile all’indirizzo https://www.ars.toscana.it/it/pubblicazioni/collana-documenti-ars/pubblicazioni-2015/2977-la-salute-dei-detenuti-in-italia-i-risultati-di-uno-studio-multicentrico-2015.html (ultimo accesso dicembre 2015)
  • World Health Organization. Hepatitis B. Luglio 2015. Disponibile all’indirizzo http://www.who.int/mediacentre/factsheets/fs204/en/ (ultimo accesso dicembre 2015)
  • Poynard T, Morra R, Halfon P, et al. Meta-analyses of FibroTest diagnostic value in chronic liver disease. BMC Gastroenterol 2007; 7: 40; http://dx.doi.org/10.1186/1471-230X-7-40
  • Castera L. Noninvasive methods to assess liver disease in patients with hepatitis B or C. Gastroenterology 2012; 142: 1293-302; http://dx.doi.org/10.1053/j.gastro.2012.02.017
  • European Association For The Study Of The Liver. EASL clinical practice guidelines: Management of chronic hepatitis B virus infection. J Hepatol 2012; 57: 167-85; http://dx.doi.org/10.1016/j.jhep.2012.02.010
  • Brancaccio G, Giuberti T, Andreone P, et al. The evolving clinical profile of chronic HBV infection – the Italian master B cohort. Hepatology 2012/10/1 – AASLD 2012; 56: 639A-640A
  • Boyd A, Lasnier E, Molina JM, et al. Liver fibrosis changes in HIV–HBV-coinfected patients: clinical, biochemical and histological effect of long-term tenofovir disoproxil fumarate use. Antivir Ther 2010; 15: 963-74; http://dx.doi.org/10.3851/IMP1659; http://dx.doi.org/10.3851/IMP1649
  • Carosi G, Rizzetto M, Alberti A, et al. Treatment of chronic hepatitis B: update of the recommendations from the 2007 Italian Workshop. Dig Liver Dis 2011; 43: 259-65; http://dx.doi.org/10.1016/j.dld.2010.10.014
  • Bruno R, Caraceni P, Coco B, et al.; Associazione Italiana per lo Studio del Fegato (AISF). Libro bianco AISF 2011. Proposta per un piano nazionale per il controllo delle malattie epatiche. Disponibile all’indirizzo http://www.webaisf.org/media/13891/libro-bianco-aisf-2011.pdf (ultimo accesso dicembre 2015)
  • Stroffolini T, Spadaro A, Di Marco V, et al.; Gr.E.Ca.S. Hospitals’ Collaborating Group. Current practice of chronic hepatitis B treatment in Southern Italy. Eur J Intern Med 2012; 23: e124-e127; http://dx.doi.org/10.1016/j.ejim.2012.03.018
  • Lok AS, McMahon BJ. Chronic hepatitis B: update 2009. Hepatology 2009; 50: 661-2; http://dx.doi.org/10.1002/hep.23190
  • Marzano A, Angelucci E, Andreone P, et al.; Italian Association for the Study of the Liver. Prophylaxis and treatment of hepatitis B in immunocompromised patients. Dig Liver Dis 2007; 39: 397-408; http://dx.doi.org/10.1016/j.dld.2006.12.017
  • Delaney WE 4th, Ray AS, Yang H, et al. Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus. Antimicrob Agents Chemother 2006; 50: 2471-7; http://dx.doi.org/10.1128/AAC.00138-06
  • Liaw YF, Leung N, Kao JH, et al.; Chronic Hepatitis B Guideline Working Party of the Asian-Pacific Association for the Study of the Liver. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int 2008; 2: 263-83; http://dx.doi.org/10.1007/s12072-008-9080-3
  • Centers for Disease Control and Prevention (CDC). Hepatitis B outbreak in a state correctional facility, 2000. MMWR Morb Mortal Wkly Rep 2001; 50: 529-32

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