[Meningococcal meningitis: a case of serogroup W in an underage migrant]

Silvia Dari, Anna Maria Cassano, Sabrina Di Lorenzo, Marta Testa, Silvia Aquilani

DOI: https://doi.org/10.7175/cmi.v11i1.1298

Abstract

Meningococcal disease is a worldwide infection associated with different forms and degrees of severity. In Europe and Italy, the most frequent capsular serogroups of Neisseria meningitidis are B and C. The incidence of the disease is higher in 0-4-year-old children and very significant (or elevated) also in adolescents and young adults. Numerous cases of serogroup W have recently been reported during episodes of mass gathering, as well as outbreaks in the African Meningitis Belt.

In 2016, also the Local Health Unit of Viterbo had to deal with a case of serogroup W meningitis in a two-year-old Nigerian migrant child, hosted in a hospitality center. Health surveillance procedures and chemoprophylaxis for contacts were quickly activated and no secondary cases were found. This experience allowed us to make considerations about the meningococcal disease from a clinical, epidemiological, and preventive point of view, emphasizing the usefulness of the current Italian surveillance System.

Keywords

Meningitis, Meningococcal; Serogroup W; Migrants; Child; Epidemiology

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References

  • Meloni C, Pelissero G. Igiene. Rozzano (MI): Casa Editrice Ambrosiana, 2007
  • ISS (Istituto Superiore di Sanità). Dati di sorveglianza delle malattie batteriche invasive aggiornati al 16 novembre 2016. V.11/12/2016. Disponibile online all’indirizzo: http://www.iss.it/binary/mabi/cont/Report_MBI_20161116_v11.pdf (ultimo accesso giugno 2017)
  • Ricciardi W, Angelillo IF, Boccia S, et al. Igiene. Medicina Preventiva. Sanità Pubblica. Napoli: Edizioni Idelson-Gnocchi, 2006
  • Centro nazionale per la prevenzione delle malattie e la promozione della salute dell’Istituto superiore di sanità. Malattie batteriche invasive (sepsi e meningiti). Disponibile all’indirizzo http://www.epicentro.iss.it/problemi/meningiti/meningite.asp (ultimo accesso giugno 2017)
  • Settore operativo di Epidemic Intelligence del gruppo di Crisi Malattie Infettive Giubileo 2015 dell’INMI L. Spallanzani di Roma. Risk assessment. Regione Lazio. IRCCS Lazzaro Spallanzani. Disponibile all’indirizzo: http://doczz.it/doc/1438729/risk-assessment-meningite-aggiornamneto-22 (ultimo accesso giugno 2017)
  • Ciofi degli Atti ML, Caporali MG, Rossi F, et al. Le meningiti batteriche in Italia: siamo di fronte ad un’emergenza nazionale? Rivista di Immunologia e Allergologia Pediatrica 2008; 01: 17-21
  • Chang Q, Tzeng YL, Stephens DS. Meningococcal disease: changes in epidemiology and prevention. Clin Epidemiol 2012; 4: 237-45; https://doi.org/10.2147/CLEP.S28410
  • CDC – Centers for Disease Control and Prevention. CDC Health Information for International Travel 2016. Atlanta (GA, USA): CDC, 2016. Disponibile all’indirizzo https://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/meningococcal-disease (ultimo accesso giugno 2017)
  • Ceyhan M, Anis S, Htun-Myint L, et al. Meningococcal disease in the Middle East and North Africa: an important public health consideration that requires further attention. Int J Infect Dis 2012; 16: e574-82; https://doi.org/10.1016/j.ijid.2012.03.011
  • Tekin RT, Dinleyici EC, Ceyhan M, et al. The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey. Hum Vaccin Immunother 2017; 13: 1182-9; https://doi.org/10.1080/21645515.2016.1268304
  • Stefanelli P, Miglietta A, Pezzotti P, et al. Increased incidence of invasive meningococcal disease of serogroup C/clonal complex 11, Tuscany, Italy, 2015 to 2016. Euro Surveill 2016; 21: pii= 30176; https://doi.org/10.2807/1560-7917.ES.2016.21.12.30176
  • Aquilani S, Dari S, Verginelli F. Meningite nella ASL di Viterbo (T15P290 15. La gestione delle emergenze sanitarie). Poster presentato al 48° Congresso Nazionale SITI, Milano 14-17 Ottobre 2015
  • Ministero della Salute. Ufficio stampa - Comunicato n. 1 del 3 gennaio 2017. Meningite, il punto della situazione in Italia. Disponibile all’indirizzo: http://www.salute.gov.it/portale/news/p3_2_1_1_1.jsp?lingua=italiano&menu=notizie&p=dalministero&id=2788 (ultimo accesso giugno 2017)
  • Mustapha MM, Marsh JW, Harrison LH. Global epidemiology of capsular group W meningococcal disease (1970-2015): Multifocal emergence and persistence of hypervirulent sequence type (ST)-11 clonal complex. Vaccine 2016; 34: 1515-23; https://doi.org/10.1016/j.vaccine.2016.02.014
  • Ispasanie E, Pluschke G, Hodgson A, et al. Characterization of vaccine antigens of meningococcal serogroup W isolates from Ghana and Burkina Faso from 2003 to 2009. F1000Res 2014; 3: 264; https://doi.org/10.12688/f1000research.3881.1
  • MacNeil JR, Medah I, Koussoubé D, et al. Neisseria meningitidis serogroup W, Burkina Faso, 2012. Emerg Infect Dis 2014; 20: 394-9; https://doi.org/10.3201/eid2003.131407
  • Cibrelus L, Medah I, Koussoubé D, et al. Serogroup W meningitis outbreak at the subdistrict level, Burkina Faso, 2012. Emerg Infect Dis 2015; 21: 2063-6; https://doi.org/10.3201/eid2111.150304
  • Osuorah D, Shah B, Manjang A, et al. Outbreak of serotype W135 Neisseria meningitidis in central river region of the Gambia between February and June 2012: a hospital-based review of paediatric cases. Niger J Clin Pract 2015; 18: 41-7
  • Hossain MJ, Roca A, Mackenzie GA, et al. Serogroup W135 meningococcal disease, The Gambia, 2012. Emerg Infect Dis 2013; 19: 1507-10; https://doi.org/10.3201/eid1909.130077
  • Ali O, Aseffa A, Bedru A, et al. The diversity of meningococcal carriage across the African Meningitis Belt and the impact of vaccination with a group A meningococcal conjugate vaccine. J Infect Dis 2015; 212: 1298-307; https://doi.org/10.1093/infdis/jiv211
  • Abad R, Lopez EL, Debbag R, et al. Serogroup W meningococcal disease: global spread and current affect on the Southern Cone in Latin America. Epidemiol Infect 2014; 142: 2461-70. https://doi.org/10.1017/S0950268814001149
  • Lucidarme J, Scott KJ, Ure R, et al. An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015. Euro Surveill 2016; 21. pii: 30395; http://dx.doi.org/10.2807/1560-7917.ES.2016.21.45.30395
  • Parent du Chatelet I, Barboza P, Taha MK. W135 invasive meningococcal infections imported from Sub-Saharan Africa to France, January to April 2012. Euro Surveill 2012; 17. pii: 20181
  • Stefanelli P, Fazio C, Neri A, et al. Imported and indigenous cases of invasive meningococcal disease W: P 1.5,2: F1-1:ST-11 in migrants’ reception centers. Italy, June-November 2014. Adv Exp Med Biol 2016; 897: 81-3; https://doi.org/10.1007/5584_2015_5006
  • Piano Nazionale Prevenzione Vaccinale – PNPV 2017-2019 (17 Gennaio 2017). Gazzetta Ufficiale della Repubblica Italiana, Serie generale, n. 41 del 18/02/2017
  • Dari S, Verginelli F, Aquilani S, et al. TBC e migranti nella ASL di Viterbo. Clinical Management Issues 2015; 9; 27-32 https://doi.org/10.7175/cmi.v9i1.1166

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