A case of aspirin-resistance probably related to glycemic excursion

Ilaria Fava, Raffaele Marfella, Giuseppe Paolisso, Maria Rosaria Rizzo

DOI: https://doi.org/10.7175/cmi.v4i4.520

Abstract

Diabetes is characterised by development of specific microvascular complications and by a high incidence of accelerated atherosclerosis. Several Authors demonstrated that post-prandial hyperglycaemia is certainly an independent risk factor of vascular complications in type 2 diabetes. The endothelial dysfunction, the oxidative stress, the post-prandial hyperglycaemia and the haemostatic and thrombotic parameters alterations are the principal causes for the cardiovascular risk increase in diabetic patient. For this reason many studies on anti-platelet therapy have been made in order to reduce thrombotic complication of diabetes mellitus. However, data suggest that the clinical efficacy of low-dose aspirin in patients with diabetes is substantially lower than in individuals without diabetes. Indeed, several evidences support the hypothesis that diabetes might represent a case of “aspirin resistance”.

Keywords

Diabetes mellitus; Aspirin resistance; Mean Amplitude of Glycemic Excursion (MAGE)

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