A severe infective endocarditis successfully treated with linezolid

Graziano Antonio Minafra, Donatella Concetta Cibelli, Maria Pipino, Vincenzo Dargenio, Francesco Ventrella

DOI: https://doi.org/10.7175/cmi.v4i1.538


Despite significant improvements in surgical and medical therapy, prosthetic valve endocarditis (PVE) is a diagnostic and therapeutic challenge and is often associated with a severe prognosis. We report a case of a 59-year-old woman, with  PVE and bacterial endocarditis (Streptococcus bovis) successfully treated with linezolid. Linezolid is a bacteriostatic oxazolidinone antibiotic that has been proven to be effective for the treatment of patients with pneumonia, skin and soft tissue infections, and infections due to Gram-positive cocci. Linezolid is not yet recognised as a standard therapy for infective endocarditis, but its use becomes a necessity when infection is due to multidrug-resistant microorganisms.


Streptococcus bovis; Prosthetic valve endocarditis; Infective endocarditis; Linezolid

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