Advanced kidney carcinoma: decision paths and therapeutic perspectives

Valentina Da Prat, Isabella Testa, Giuseppe Procopio



Treatment of kidney cancer represents an open challenge for scientists and clinicians. In fact,renal tumours are resistant to virtually all of the currently available chemotherapeutics, beingonly partially sensitive to immunological agents. During the last decade, knowledge of geneticbasis of cancer has grown considerably. This has lead to an authentic revolution in the clinicalmanagement of renal tumours: the introduction of targeted therapies. Novel agents addressangiogenic signalling pathways through inhibition of the vascular endothelial growth factor(VEGF) or the mammalian target of rapamycin (mTOR). However, there is still no greatevidence favouring one drug over the others. This underlines the need for decision-making toolsin renal cell cancer treatment, in order to rationalise the choice of appropriate targeted agentsand to enable individualised clinical management. This is a brief overview on the state of theart of the treatment of metastatic renal tumour.


Renal carcinoma; Oncology; Antiangiogenic therapy; Tyrosin kinase inhibitors

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