Atypical presentation of Non-Hodgkin Lymphoma (NHL): a case report

Fabiola Mastropietro, Alessandra Piccini, Giulia Lucignani, Alfonso Rubino, Giancarlo Fiermonte



Lymphomas infrequently cause peripheral nerve complications. These syndromes mostly occur by direct compression or infiltration of nerves (neurolymphomatosis), but may also be due to a remote effect as paraneoplastic syndromes, neurotoxic complications of chemotherapy, antibody-mediated or autoimmune mechanisms.

We report the case of a 60-year-old woman who presented with a complex peripheral nervous system involvement as initial manifestation of Non-Hodgkin Lymphoma (NHL). This case sheds light on “protean” mechanism of peripheral nerve complications during the course of NHL and related diagnostic dilemma.


Neurolymphomatosis; Paraneoplastic syndrome; Non-Hodgkin Lymphoma

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