Prophylaxis of venous thrombosis in patients with spontaneous intracerebral bleeding

Emanuele Rezoagli, Walter Ageno, Luca Masotti, Daniel Godoy, Mario Di Napoli, Maurizio Paciaroni, Alejandro Rabinstein



Spontaneous intracerebral haemorrhage (SIH) represents a severe clinical event that is associated with high rates of mortality and morbidity. Only a minority of SIH patients receive surgical treatment, whereas the majority are treated conservatively. Venous thromboembolism (VTE) is one of the most common complications in SIH patients and a potential cause of death. Because of the lack of adequate evidences from the literature, the risk to benefit ratio of pharmacologic prophylaxis of VTE, represented on the one hand by hematoma enlargement and/or rebleeding and on the other hand by an expected reduction of the risk of VTE, remains controversial. Mechanical prophylaxis is a potentially safer alternative, but the efficacy of this approach is uncertain. In the absence of specific clinical guidelines containing clear-cut recommendations, physicians have insufficient tools to assist their therapeutic decisions.


Intracranial bleeding; Deep vein thrombosis; Pulmonary embolism; Prophylaxis; Low molecular weigh heparin; Unfractionated heparin; Physical methods

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