The Role of Carbon Dioxide Laser Therapy in Penile Kaposi’s Sarcoma: A Case Series of Three HIV-Negative HHV-8-Positive Patients

Tullio Torelli, Biagio Paolini, Mario Achille Catanzaro, Nicola Nicolai, Maurizio Colecchia, Davide Biasoni, Alberto Macchi, Silvia Stagni, Antonio Tesone, Roberto Salvioni

DOI: https://doi.org/10.7175/cmi.v13i1.1403

Abstract

Kaposi’s sarcoma (KS) is a rare tumor of vascular origin. It is quite common in HIV patients. It is rarely located on the glans penis, especially in HIV-negative patients (just some tens in the literature). Owing to the rarity of the disease, both the real impact on survival and the most suitable therapy are not known.

However, in this 3-patient case series, carbon dioxide laser therapy was effective both for local control and survival. In fact, two late relapses but no disease-related death were recorded. Probably, KS in HIV-negative patients is a slowly progressive disease, not so aggressive as in HIV-positive patients. Laser therapy is easy, fast, and cheap, and may treat the disease radically.

If these data are confirmed by further studies, in the foreseeable future, laser therapy may become the gold standard for treating HIV-negative patients affected by penile KS.

Keywords

Penile Neoplasms; Laser Therapy; Sarcoma, Kaposi; Herpesvirus 8, Human; Infection

Full Text:

HTML PDF

References

  • Mukai MM, Chaves T, Caldas L, et al.Primary Kaposi’s sarcoma of the penis. An Bras Dermatol 2009; 84: 524-6; https://doi.org/10.1590/S0365-05962009000500013
  • Rescigno P, Di Trollo R, Buonerba C, et al. Non-AIDS-related Kaposi’s sarcoma: a single-institution experience. World J Clin Oncol 2013; 4: 52-7; https://doi.org/10.5306/wjco.v4.i2.52
  • Micali G, Nasca MR, De Pasquale R, et al. Primary classic Kaposi’s sarcoma of the penis: report of a case and review. J Eur Acad Dermatol Venereol 2003; 17: 320-3; https://doi.org/10.1046/j.1468-3083.2003.00747.x
  • Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 266: 1865-9; https://doi.org/10.1126/science.7997879
  • Morelli L, Pusiol T, Piscioli F, et al. Herpesvirus 8-Associated Penile Kaposi’ s sarcoma in an HIV-Negative Patient: First report of a solitary lesion. Am J Dermatopathology 2003; 25: 28-31; https://doi.org/10.1097/00000372-200302000-00006
  • Seleit I, Attia A, Maraee A, et al. Isolated Kaposi Sarcoma in two HIV negative patients. J Dermatol Case Rep 2011; 2: 24-6; https://doi.org/10.3315/jdcr.2011.1067
  • Zargari O. Exclusive penile Kaposi’s sarcoma: report of an HIV-negative man successfully treated with radiotherapy. J Eur Acad Dermatol Venereol 2006; 20: 318-20; https://doi.org/10.1111/j.1468-3083.2006.01423.x
  • De Rose AF, Justich M, Mantica G, et al. Kaposi’s sarcoma : an unusual penile lesion in a HIV negative patient. Arch It Urol Androl 2017; 89: 164-5; https://doi.org/10.4081/aiua.2017.2.164
  • Kuriyama Y, Shimuzu A, Yamada K, et al. Case of classic Kaposi sarcoma of the penis successfully treated with radiotherapy. J Dermat 2018; 45: e175-e176; https://doi.org/10.1111/1346-8138.14220
  • Brambilla L, Bellinvia M, Tourlaki A, et al. Intralesional vincristine as first-line therapy for nodular lesions in classic Kaposi sarcoma: a prospective study in 151 patients. Br J Dermatol 2010; 162: 854-9; https://doi.org/10.1111/j.1365-2133.2009.09601.x
  • Ghyka G, Alecu M, Halalau F, et al. Intralesional human leukocyte interferon treatment alone or associated with IL-2 in non-AIDS related Kaposi’s sarcoma. J Dermatol 1992; 19: 35-9; https://doi.org/10.1111/j.1346-8138.1992.tb03176.x
  • Celestin Schartz NE, Chevret S, Paz C, et al. Imiquimod 5% cream for treatment of HIV-negative Kaposi sarcoma skin lesion: a phase I to II, open-label trial in 17 patients. J Am Acad Dermatol 2008; 58: 585-91; https://doi.org/10.1016/j.jaad.2007.11.005
  • Regneir-Rosencher E, Guillot B, Dupin N. Treatments for classic Kaposi sarcoma: a systematic review of the literature. J Am Acad Dermatol 2013; 68: 313-31; https://doi.org/10.1016/j.jaad.2012.04.018
  • Chun YS, Chang SN, Park WH. A case of classical Kaposi’s sarcoma of the penis showing a good response to high-energy pulsed carbon dioxide laser therapy. J Dermat 1999; 26: 240-3; https://doi.org/10.1111/j.1346-8138.1999.tb03464.x
  • Kolios G, Kaloterakis A, Filiotou A. Gastroscopic findings in Mediterranean Kaposi’s sarcoma (non-AIDS). Gastrointest Endosc 1995; 42: 336-9; https://doi.org/10.1016/S0016-5107(95)70133-8

Refbacks

  • There are currently no refbacks.




© SEEd srl