Myeloid Sarcoma Involving Kidneys: From Diagnosis to Treatment. Case Report and Literature Review

Francesca Guidotti, Angelo Gardellini, Maddalena Feltri, Michelle Zancanella, Vittoria Saccà, Luciana Ambrosiani, Mauro Turrini

DOI: https://doi.org/10.7175/cmi.v14i1.1460

Abstract

Myeloid sarcomas (MS) are rare extramedullary hematological tumors which generally occur during the natural course of acute myeloid leukemia or chronic myeloid leukemia. Rarely, their onset precedes peripheral blood and bone marrow manifestations of disease. Common sites of involvement are skin, bone, soft tissue, lymph nodes, reproductive or digestive organs, and central nervous system.

Herein, we report the case of a 72-year-old man affected by JAK2 V617F mutated myeloproliferative neoplasm who developed MS involving collecting system of both kidneys. MS and MS-related obstructive nephropathy were the first signs of the acute evolution of a known chronic hematological malignancy, preceding by some weeks the onset of leukocytosis.

 

Keywords

Sarcoma; Acute Myeloid Leukemia; Kidney

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References

  • Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016; 127: 2391-405; https://doi.org/10.1182/blood-2016-03-643544
  • Wang HQ, Li J. Clinicopathological features of myeloid sarcoma: Report of 39 cases and literature review. Pathol Res Pract 2016; 212: 817-24; https://doi.org/10.1016/j.prp.2016.06.014
  • Al-Khateeb H, Badheeb A, Haddad H, et al. Myeloid sarcoma: clinicopathologic, cytogenetic, and outcome analysis of 21 adult patients. Leuk Res Treat 2011; 2011: 523168; https://doi.org/10.4061/2011/523168
  • Bakst RL, Tallman MS, Douer D, et al. How I treat extramedullary acute myeloid leukemia. Blood 2011; 118: 3785-93; https://doi.org/10.1182/blood-2011-04-347229
  • Li JM, Liu WP, Zhang MH, et al. Chen Clinicopathologic and immunophenotypic analysis of myeloid sarcoma. Zhonghua Bing Li Xue Za Zhi 2006; 35: 606-11
  • Park HJ, Jeong DH, Song HG, et al. Myeloid sarcoma of both kidneys, the brain, and multiple bones in a nonleukemic child. Yonsei Med J 2003; 44: 740-3; https://doi.org/10.3349/ymj.2003.44.4.740
  • Agrawal V, Gupta A, Gupta R, et al. Nonleukemic granulocytic sarcoma of kidney with mixed phenotype blasts: a diagnostic dilemma. Indian J Pathol Microbiol 2011; 54: 606-8; https://doi.org/10.4103/0377-4929.85111
  • Palanisamy A, Persad P, Koty PP, et al. Donor-derived myeloid sarcoma in two kidney transplant recipients from a single donor. Case Rep Nephrol 2015; 2015: 821346; https://doi.org/10.1155/2015/821346
  • Wang P, Li Q, Zhang L, et al. A myeloid sarcoma involving the small intestine, kidneys, mesentery, and mesenteric lymph nodes: A case report and literature review. Medicine (Baltimore) 2017; 96: e7934; https://doi.org/10.1097/MD.0000000000007934
  • Traweek ST, Arber DA, Rappaport H. Extramedullary myeloid cell tumors: An immunohistochemical and morphologic study of 28 cases. Am J Surg Pathol 1993; 17: 1011-9; https://doi.org/10.1097/00000478-199310000-00006

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