Atypical presentation of Non-Hodgkin Lymphoma (NHL): a case report

Fabiola Mastropietro, Alessandra Piccini, Giulia Lucignani, Alfonso Rubino, Giancarlo Fiermonte

DOI: https://doi.org/10.7175/cmi.v8i4.942

Abstract

Lymphomas infrequently cause peripheral nerve complications. These syndromes mostly occur by direct compression or infiltration of nerves (neurolymphomatosis), but may also be due to a remote effect as paraneoplastic syndromes, neurotoxic complications of chemotherapy, antibody-mediated or autoimmune mechanisms.

We report the case of a 60-year-old woman who presented with a complex peripheral nervous system involvement as initial manifestation of Non-Hodgkin Lymphoma (NHL). This case sheds light on “protean” mechanism of peripheral nerve complications during the course of NHL and related diagnostic dilemma.

Keywords

Neurolymphomatosis; Paraneoplastic syndrome; Non-Hodgkin Lymphoma

Full Text

HTML PDF

References

  • Antoine JC, Camdessanché JP. Peripheral nervous system involvement in patients with cancer. Lancet Neurol 2007; 6: 75-86; http://dx.doi.org/10.1016/S1474-4422(06)70679-2
  • Kelly JJ, Karcher DS. Lymphoma and peripheral neuropathy: a clinical review. Muscle Nerve 2005; 31: 301-13; http://dx.doi.org/10.1002/mus.20163
  • Freeman R. Autonomic peripheral neuropathy. Lancet 2005; 365: 1259-70; http://dx.doi.org/10.1016/S0140-6736(05)74815-7
  • Koike H1, Watanabe H, Sobue G. The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. J Neurol Neurosurg Psychiatry 2013; 84: 98-106; http://dx.doi.org/10.1136/jnnp-2012-302833
  • Tomita M, Koike H, Kawagashira Y, et al. Clinicopathological features of neuropathy associated with lymphoma. Brain 2013; 136(Pt 8): 2563-78; http://dx.doi.org/10.1093/brain/awt193
  • Briani C, Vitaliani R, Grisold W, et al; PNS Euronetwork. Spectrum of paraneoplastic disease associated with lymphoma. Neurology 2011; 76: 705-10; http://dx.doi.org/10.1212/WNL.0b013e31820d62eb
  • Choi YJ, Shin JA, Kim YH, et al. Neurolymphomatosis of brachial plexus in patients with Non-Hodgkin’s Lymphoma. Case Rep Oncol Med 2013; 2013: 492329. Epub 2013 Nov 12
  • Giometto B, Vitaliani R, Lindeck-Pozza E, et al. Treatment for paraneoplastic neuropathies. Cochrane Database Syst Rev 2012; 12: CD007625.
  • Viala K, Béhin A, Maisonobe T, et al. Neuropathy in lymphoma: a relationship between the pattern of neuropathy, type of lymphoma and prognosis? J Neurol Neurosurg Psychiatry 2008; 79: 778-82; http://dx.doi.org/10.1136/jnnp.2007.125930

Statistics

Abstract: 2012 views
HTML: 2521 views
PDF: 600 views

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.