Basilar Artery Occlusion: Clinical Management and Therapy

Marco Sparaco 1

1 Division of Neurology, Department of Neurosciences, Azienda Ospedaliera “San Pio”, Benevento, Italy

Abstract

Basilar artery occlusion is a potentially life-threatening subset of the larger category of posterior circulation strokes, carrying > 80% fatality rate without treatment. This condition accounts for about 1% to 4% of all ischemic strokes and is generally related to local atherothrombosis or cardioembolism.

Diagnosis can be challenging because presenting symptoms are often non focal, such as headache, dizziness, and vertigo. The onset of the symptomatology can be abrupt without preceding events, abrupt with prodromal symptoms, or progressive and stuttering. Finally, the severity of clinical presentation may range from isolated cranial nerve palsies to tetraplegia, locked-in state, or coma.

If basilar artery occlusion is readily recognized and confirmed with the aid of neuroimaging, intravenous thrombolysis or endovascular treatment can be undertaken immediately in order to recanalize the occluded artery and thus reduce mortality and improve outcome.

Keywords: Stroke; Basilar Artery Occlusion; Headache Disorders; Magnetic Resonance Image; Thrombolysis

Occlusione dell'arteria basilare: gestione clinica e terapia

CMI 2018; 12(1): 67-76

https://doi.org/10.7175/cmi.v12i1.1363

Clinical Management

Corresponding author

Marco Sparaco

Division of Neurology,

Department of Neurosciences,

Azienda Ospedaliera “San Pio”,

Via Pacevecchia 53,

82100 Benevento, Italy

Phone: +0039-0824-57492;

Fax: +0039-0824-57293

E-mail: marcosparaco@alice.it


Received: 15 June 2018

Accepted: 20 September 2018

Published: 9 October 2018

Introduction

The vertebrobasilar arterial system receives only 20% of cerebral blood flow and supplies the posterior portion of the brain including the brainstem, the thalami, the cerebellum, and parts of the occipital and temporal lobes [1,2]. Posterior circulation ischemia (PCI) is a clinico-pathological condition associated with an infarction within the vertebrobasilar arterial system and is characterized by a complex symptomatology, course, and outcome [1,2]. PCI accounts for about 20-25% of all ischemic strokes and has an adjusted incidence of 18 per 100.000 person-years (95% confidence interval—CI: 10/100,000 to 26/100,000) [1,2]. Basilar artery occlusion (BAO) is a potentially life-threatening subset of PCI, carrying > 80% fatality rate without treatment and accounts for about 1% to 4% of all ischemic strokes [3]. BAO still represents one of the most challenging conditions to diagnose and manage. Despite better imaging techniques, in fact, the diagnosis of this condition is often delayed, especially because in many cases presenting symptoms are non-focal, such as headache, dizziness, and vertigo [1-3]. The aim of this article is to provide clinicians with an easy and reliable tool for promptly recognizing and treating BAO.

Etiology

The most frequent causes of BAO are local thrombosis and artery-to-artery thromboembolism originating from arteriosclerotic lesions [3]. Other important etiologies are cardiac emboli and vertebral artery dissections, affecting respectively 30-35% and 6-8% of patients [3]. Atherosclerosis preferentially involves the proximal and middle segments of the basilar artery (BA), while the occlusion of the distal segment is typically indicative of an arterioembolic or cardioembolic event [3-5].

Vertebrobasilar dolichoectasia, an anatomic variant consisting of enlargement and dilatation of the vertebral/basilar artery, has been shown also to predispose to BAO through a reduction in flow velocity leading to local thrombus formation [1,6].

Rare causes include arteritis, meningitis, cervical trauma, coagulopathy, aneurysms, hereditary arteriopathies, as well as complications after endovascular procedures and neurosurgery [3].

Finally, we recently described a case of reversible stenosis of the BA due to hemoconcentration, a condition frequently found in psychiatric patients, especially if suffering from a severe depression [7].

Clinical Features

Several aspects, described hereafter, contribute to make BAO one of the most challenging conditions to diagnose and manage:

Presenting symptoms are often non-focal

Most common premonitory symptoms of BAO are dizziness and vertigo, followed by headache and neck pain [3,8,9].

Dizziness and vertigo are two terms used interchangeably by patients to indicate non-specific symptoms accounting for about 4 million emergency department visits annually in the United States [9]. Dizziness is usually described as a feeling of light-headedness or lack of mental clarity [10]. Vertigo more specifically describes a sensation of spinning and usually indicates dysfunction of the peripheral vestibular or central vestibule-cerebellar system [6]. Vertigo and/or dizziness caused by BAO are usually associated to other brainstem or cerebellar symptoms [6]. However, when vertigo is the only symptom and the neurologic examination is normal is not easy to establish the central or peripheral origin of the symptomatology. In these cases the head-impulse-nystagmus-test of skew (HINTS) can be a useful bedside test to distinguish between vertigo caused by peripheral or central lesions [11].

In patients with PCI headache is a common presenting symptom that seems to be caused by irritation of trigeminovascular afferents located in brainstem [12]. In a study by Ferbert et al. of 85 patients with BAO, headache was reported in 25.8% of cases on admission [8]. The headache occurred during the 2 weeks before the stroke and had a predominantly occipital localization. The onset was both sudden and the main complaint, so that initially it was considered subarachnoid hemorrhage [8].

The onset of symptomatology is quite variable

Based on the symptoms onset, three major clinical types of BAO presentation have been described [3,13]:

The clinical picture varies depending on the site and type of the BA obstruction

Owing to different degrees of the brainstem involvement, the severity of the clinical presentation may range from isolated cranial nerve palsies to tetraplegia, locked-in state, or coma [3].

Differential diagnosis

Any rapidly progressive clinical condition with multiple cranial nerve dysfunctions (i.e. cranial polyradiculitis, Miller-Fisher syndrome, botulism, or myasthenic crisis) can potentially be mistaken for a brainstem lesion.

Toxic or metabolic disturbances, such as drug abuse or hypoglycemia, may initially present with features resembling cerebrovascular disease. Central pontine myelinolysis and Wernicke’s encephalopathy usually present with brainstem deficits. A history of rapid correction of hyponatremia or of poor nutritional intake will clarify the diagnosis.

Neuroinflammatory disorders, such as sarcoidosis or Behçet’s disease, may acutely affect the brainstem. However, these diseases often have systemic clinical features which are useful for correctly guiding the diagnosis.

Central nervous system (CNS) infection by viruses (i.e. Epstein-Barr virus or West Nile virus), bacteria (i.e., Listeria monocytogenes), or fungi may mimic stroke [16]. Clinical findings, cerebrospinal fluid examination, and magnetic resonance imaging (MRI) features usually help to get a correct diagnosis.

Acute intracranial hemorrhage affecting brainstem, subarachnoid hemorrhage, and tumor mimicking ischemic stroke can be differentiated from BAO only by imaging [16].

Extensor jerks and spasms and decerebrate posturing arising with BAO are sometimes mistaken for grand mal seizures [17].

Finally, in the presence of a headache associated with posterior circulation symptoms, a clinician should also consider the diagnosis of a migraine with brainstem aura. This rare type of primary headache disorder, previously referred to as basilar migraine, is characterized by attacks preceded and/or accompanied by transitory focal neurologic symptoms pointing to dysfunction in the region supplied by the BA and its branches [18]. The diagnosis is based on the finding of at least two migraine attacks accompanied by at least two of the following fully reversible symptoms: dysarthria, vertigo, tinnitus, impaired hearing, double vision, ataxia, and decreased level of consciousness [18,19].

Investigation

Computed tomography (CT), contrast-enhanced CT angiography (CTA), MRI, magnetic resonance angiography (MRA), and Doppler sonography can be used in the acute setting to evaluate patients with suspected BAO. If a patient is a candidate for thrombolytic therapy, neuroimaging should be performed as soon as possible to reduce the door to needle time.

Acute Treatment

Acute BAO treatment aims to restore the cerebral blood flow in the occluded vessel and salvage brain tissue. It has been shown that BA recanalization can substantially enhance a patient’s chances of survival and of good functional recovery [3]. A meta-analysis of 45 studies (n = 2056) on acute BAO, in particular, has shown that recanalization of BA results in a two-fold reduction in mortality and 1.5-fold reduction in death or dependency [32].

Furthermore, the existence of a relationship between the time from symptom onset to arterial recanalization and clinical outcome has been widely demonstrated. As evidenced in the BASICS registry, a significantly increased risk of poor outcome seems to occur when recanalization therapy is started > 6 hours after the estimated time of BAO [33]. In this regard, it is necessary to clarify the concept of “time to recanalization therapy”, i.e. the interval between estimated time of BAO and start of recanalization therapy. Since BAO is preceded by prodromal symptoms in > 60% of cases [3,34,35], most of these patients are likely to be excluded from any acute therapeutic option if it is considered as an inclusion criterion the time of onset of any symptom to treatment. Therefore, as suggested in the BASICS registry, the estimated time of BAO is defined as “time of onset of acute symptoms leading to clinical diagnosis of BAO or, if not known, last time the patient was seen normal before onset of these symptoms” [33].

Acute treatment options for BAO include intravenous fibrinolysis (IVT), intra-arterial thrombolysis (IAT), and/or endovascular mechanical treatment [1-3,23].

Over the past decade, treatment for acute ischemic stroke has evolved to include both IVT and endovascular procedures. Phan et al. analyzed six randomized controlled trials involving 1943 patients to assess the functional outcomes and complications of IVT with and without endovascular treatment. In this study, patients who received IVT with endovascular treatment had significantly higher rates of excellent functional outcomes (mRS 0-1) (95% CI: 1.29-2.39; RR: 1.75) in comparison with those who received IVT alone. Endovascular treatment increased the RR of a good functional outcome by at least 30% compared to IVT alone [50].

Perfect timing for endovascular treatment in BAO is not well established. Recently, published American guidelines suggest to perform MT in PCI only within 6 hours from stroke onset [51]. However, most centers, considering the poor prognosis associated with BAO, apply recanalization therapies for this pathology up to 12-24 hours after symptom onset [52].

An analysis of 19 published cohorts of patients with BAO showed that higher recanalization rates, such as those obtained with endovascular mechanical treatments, decrease mortality but do not necessarily translate into better outcomes [3,53]. Therefore, even if it is widely agreed that significant survival after BAO requires rapid access to revascularization, straightforward evidence about efficacy of endovascular therapy (i.e. IAT or MT) over systemic fibrinolysis in basilar stroke is still missing [53].

In-Hospital Management and Secondary Prevention

Patients with BAO should be carefully monitored with MRI to evaluate burden lesion and cerebellar edema. The latter generally peaks 3 to 5 days after infarction and may cause compression of the fourth ventricle and/or herniation [9]. After initial stabilization, patients should undergo an extensive systematic etiological work-up including the following assessments:

Patients should be placed on continuous cardiac monitoring to detect cardiac arrhythmias (i.e. atrial fibrillation, etc.) and to check the blood pressure. Patients with BAO may be particularly sensitive to changes in blood pressure [9]. However, so far the balance of risk and benefit in lowering blood pressure in these cases is not yet clear. In a study that analyzed the association between blood pressure and stroke in patients undergoing endarterectomy for symptomatic carotid stenosis it was found higher risk of stroke at lower blood pressure, especially if systolic blood pressure < 140 mmHg [54]. There are no similar studies in patients with BAO, but the same possibility of hemodynamic insufficiency at lower blood pressures exists. Therefore, caution is advised in lowering the pressure aggressively in these patients, particularly if they have limited or absent posterior communicating arteries as well as other collateral flow abnormalities [1].

The choice of the appropriate medical therapy for secondary prevention of BAO should be based on the causative stroke mechanism (i.e. cardioembolic, atherosclerotic, etc.) as well as on the risk stratification for recurrence [1-3,30]. Therefore, possible medical treatments include antiplatelet agents or anticoagulants, as well as lipid-lowering drugs. Recommended treatment is detailed in recent guidelines [51,55]. In patients with indications for anticoagulation (i.e. atrial fibrillation), treatment should be started generally within two weeks after an acute ischemic stroke, to avoid the risk of hemorrhagic transformation of the infarct.

Key points

Proposed Algorithm for Acute BAO Management

img11_01.jpg

BAO = basilar artery occlusion; CT = computed tomography; CTA = computed tomography angiography; MRA = magnetic resonance angiography; MRI = magnetic resonance imaging

*“Time of onset of acute symptoms leading to clinical diagnosis of BAO or, if not known, last time the patient was seen normal before onset of these symptoms” [33].

Funding

This article has been published without the support of sponsors.

Conflicts of interests

The author declares he has no competing financial interests concerning the topics of this article.

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